Evaluation of The Hepatoprotective Effect of Plantago major Extract in A Rifampicin-Isoniazid Induced Hepatitis Rat Model

Tuberculosis (TB) is an ancient human disease caused by Mycobacterium tuberculosis which affects the lungs, making pulmonary most common presentation. Herbal medicine began to be developed as hepatoprotection. The hepatoprotection effects of Plantago major extract on serum glutamic pyruvic transaminase (SGPT), liver tissue Malondialdehyde (MDA), and histopathological changes were evaluated in rifampicin isoniazid-induced hepatitis rats. Thirty male Wistar rats divided into 6 groups: Group I received 1 % PGA, with induced remaining groups isoniazid 50 mg/kg BW/day, group II was only given isoniazid, III curcuma 10.8 BW/day IV (PM1), V (PM2), VI (PM3) at a dose 20.3, 40.5, 81 respectively. treated for 28 days. Administration (20.3 40.5 BW/day) inhibited elevation SGPT MDA levels, less portal inflammation than negative control group. higher had SGPT, MDA, percentage equivalent 20.3 BW can inhibit elevated SGPT. exerts dose-dependent rifampicin-isoniazid rat model reducing levels well inflammation. HIGHLIGHTS To knowledge authors, there has been no comprehensive work dedicated antituberculosis drugs administration showed hepatoprotector effects, evidenced inhibition lower controls used herbal that juxtaposed main drug TB patients GRAPHICAL ABSTRACT